Microsoft has a two-game deal with Comedy Central for its South Park license, which implies that another Xbox Live Arcade game could be on the way, following 2009's South Park: Let's Go Tower Defense Play!
Joystiq uncovered that nugget in a discussion with Prithvi Virasinghe of 345 Games, which is the games production arm of Comedy Central and Spike TV. Asking if his studio would be doing anything with South Park any time soon, Virasinghe explained the show was currently tied up in a first-party development agreement with Microsoft.
"They're doing a second game as well. After that, that first-party exclusivity window expires, and we get a shot of taking that back," Virasinghe told Joystiq.
Second South Park Game Headed Exclusively to Xbox 360 [Joystiq]