Ballpoint pens: bad for math class, good for having a gorgeous visual aesthetic in a game. Case in point: Ballpoint Universe, an indie sidescrolling shooter drawn entirely with ballpoint pen. You play as a doodle called...Doodle. Check out the trailer.
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If this looks good to you, you can try out the demo here and vote for Ballpoint Universe on Steam Greenlight here. The game drops sometime in May for $4.99 on Desura.