The makers of The Maw and Splosion Man announced their next game at PAX 2009: Comic Jumper, The Adventures of Captain Smiley. Watch the trailer and try not to laugh.
Twisted Pixel people aren't saying much about the game other than 1) It's so early in pre-production that there is no release date and 2) The game won't be like Comix Zone because, at the very least, it's about a hero who travels through several different kinds of comic books.
The official Twisted Pixel site may have more info about the game some day.