This is a box of "Marios," a novelty product pitched by Mario Williams, a new member of the Buffalo Bills' defensive line, and currently on sale in Buffalo-area grocery stores such as Top's. Proceeds from the sale of this cereal benefit patients and families of children being treated at an area cancer institute. The nameplate font certainly evokes the title screen of Super Mario Bros.

The real question is, what the hell is an enormous Sonic the Hedgehog doing behind Mario?

[h/t mr_raccoon]