This is, basically, a multistage BioShock playset, in LEGO spanning the game's opening plane crash, to the lighthouse and to the Medical Pavilion and beyond. It is fantastic, the work of Imagine Rigney at MOCpages, built for Chicago's Brickworld 2011 expo and noticed today by the gang at Irrational Games. There are many, many more pictures and closeups at the link.
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Now build it out of the superior plastic brick, Mega Bloks.