We've seen it in a sequence in Doom already, but that was a movie about an FPS, so it doesn't count. This, though - an FPS sequence in the TV show Lost - counts.
Counts for...something. What it is, exactly, we're not sure. But hey, since there's a very good chance the writers and creators of Lost play a ton of video games, and the viewers of Lost play a ton of video games, stuff like this probably just becomes second-nature.