This is Vanquish, a new game by Shinji Mikami, the creator of the Resident Evil series.
What you see in this clip is just about all we know about the game. There's an attack on the United States (aliens?), there's real actors in it, and you'll be playing some guy that looks like an albino Master Chief. Oh, and Okami producer Atsushi Inaba is also involved
With the trailer being entirely made up of either pre-rendered or full-motion video sequences, there's little to go on about what you'll actually be doing, but hey, having helped found Platinum Games (the developers behind Bayonetta and Madworld) a few years back, it's nice to at least see what Mikami's been working on all this time.
Wondering about platforms? So are we. No platforms announced, but it looks like a 360/PS3 job to us.