Happily, the newest official patch for Skyrim will allow the game to make use of up to 4 Gigabytes of RAM, as opposed to its previous ceiling of 2GB. This had previously been accomplished via the Large Address Aware hack, but that method had been blocked by a previous patch from Bethesda.
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I'm no computer science guy, so apologies for my ignorance. I don't understand why games/programs can't be written to use as much RAM as is available on the system. I get why there's a minimum required RAM to run a game/program, but a max?!?!