The RE Wikia recommends exposing his weak spot with a submachine gun, and then whamming him with a rocket launcher. But there’s an easier way to kill him. If you throw at least one golden egg at him, it takes out most of his health. This weakness isn’t even a bug; exploiting it will cause Salazar to fall backwards and call the protagonist Leon Kennedy a “worm.”

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Here’s the funniest part: There isn’t a biological reason for the parasite queen to react this way to a chicken egg. The egg debuff comes from Salazar himself. This is hinted at if you undertake the merchant quest “The Disgrace of the Salazar Family,” which asks you to deface a portrait of Salazar. The painting is completely impervious to conventional weapons such as knives and guns. The only way to complete this quest is to wait for one of the nearby chickens to lay an egg, and then throw the item at the portrait. So if you completed this side quest, it’s a fun hint for finding the easiest method of defeating the final boss. Merchant quests are a new feature to the RE4 remake, so it’s likely that this trick wasn’t available in the original game.

I find it creatively inspired that Salazar was such a loser, he managed to debuff his own chimera. Keep an eye out for those golden eggs if you want to play a nasty prank on him.