"Never say never. I would do it again, in some fashion." South Park creator Matt Stone mentions the possibility of doing another South Park game in a recently published pre-Stick of Truth-launch interview with IGN.
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Stick of truth was actually a solid game. Now that they've laid the groundwork I think the series would be a prime canidate for doing some episodic dlc's. Put out a 4-6 hr quest for 15 bucks I think people would bite