Spoilers: it would basically be the best thing, judging from these mash-ups by renegade21. I mean, Toy Story x Mass Effect, for example...it feels so right, no?
It's not the only mash-up renegade21's concocted. Here are a few more. Enjoy!
The Last of Us x Monsters, Inc
Red Dead Redemption X Toy Story
Metal Gear Solid x Up
Shadow of the Colossus x Ratatouille
Tomb Raider x Brave
Mass Effect x Toy Story