Fremen

In addition to Dune’s iconic sand worms, Arrakis is also home to the Fremen, a desert civilization with a complex religious history that’s in a forever war against whichever great House happens to be occupying the planet at the time. In addition to using guerrilla warfare to sabatoge Spice operations, the Fremen can also ride worms and partake in experiments with worm piss and other byproducts that do all kinds of weird stuff but are also life-threateningly toxic to most people.