Spice

In Dune’s universe, all economic activity revolves around a chemical substance called Spice. Otherwise known as “Melange,” people can use it to get high and then do complex navigation computations to pilot ships through space. No spice, no space travel, which is why it’s always at the center of every major power dispute in Dune.
If Spice were plentiful, it would simplify things. Instead, Spice can only be harvested from the poop of massive alien worms on a giant desert planet called Arrakis. Much geopolitical turmoil ensues as rival powers negotiate and fight with one another over the Spice trade. Melange doubles as status symbol for rich families and a psychedelic that can help the Bene Gesserit and others tap into the more mystical side of Dune’s universe.