Bene Gesserit

The Bene Gesserit is a Mother School on the planet Wallach IX that trains women in a number of almost superhuman skillsets like hyper-perceptiveness and even the ability to manipulate others with their voices. Successful graduates go on to become Truthsayers for powerful families and Houses throughout the galaxy while those who show special promise are referred to as Reverend Mothers. They also try to enlist the would-be wives of emperors and other royalty in their school in order to increase their reach and power.

Beyond generally being the witches of the Dune universe, the Bene Gesserit’s larger goals is to bring about the birth of a super-being called the Kwisatz Haderach through thousands of years of genetic research and carefully arranged marriages. This ultimately ends up being Timothée Chalamet’s Paul Atreides in the movies. His mother, Lady Jessica (Rebecca Ferguson) is a member of the Bene Gesserit and the Mother Superior of that era is the one who puts his hand in the “fear is the mind killer” box.