2.1.0 brings with it a competitive game mode based on Diablo II's online ladders, called Seasons, and a new type of endgame dungeon: Greater Rifts.
Both of these new additions will be supported by another newly introduced feature, the leaderboards, deepening the competitive aspect of the game—and of course, there's hundreds of bugfixes and balance changes included as well.
The video above from Blizzard explains the biggest changes, and for a closer look, you can check out the patch notes here.
Patch 2.1.0 Now Live [Battle.net]
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