Like this, apparently.
I have no idea what the hell is going on in this screenshot, but I'm interested in finding out. House M.D. seems to be a puzzle game of sorts, translating the rather dry diagnosis elements of the show into more readily-digestible puzzle bits. You are still using logic and reasoning in a way...you're just doing it in a more colorful fashion.
The game allows you to listen to your own music while you play, and there's a Facebook tie-in that lets you diagnose and save your friends from hideous rare diseases that are almost guaranteed to not be lupus. It's NEVER lupus.
I think I would have preferred a fighting game, but this will do in a pinch. House M.D. is now available on the App Store for $2.99.
Note: I called it an NBC show because it is produced in association with Universal Media Studios, the production arm of NBC Universal Television Group. This confused some of you, so I just put FOX up there.