FaceRig is a piece of software that will use your webcam to track your face (and facial movements) then transform it into something a little (or a lot) less human.
Its makers say it'll work across popular platforms like Skype and Twitch, while you'll also be able to use the program to make animated clips.
It's still in development, but you can back it over on Indiegogo; $5 will get you a copy so you can mess around with the beta.
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FaceRig [Indiegogo, via Incredible Things]