Today we found out that the hero of Assassin's Creed III, who calls himself Connor, was born Ratohnhaké:ton.
Here at Kotaku, we consider it our duty to answer important questions like "How the hell do I pronounce Ratohnhaké:ton?" So I asked Assassin's Creed publisher Ubisoft for an official guide. Their response:
Ra-doon-ha-gay-doo'
So there you go.