There are a lot of cool trailers here, but I'm probably most excited for Cuphead, the game styled after 1930's animation:
Ori and the Blind Forest is an adventure platformer that looks oh-so-pretty:
Grave is some kind of open-world horror game where reality shifts and changes. Looks different enough to possibly refresh my interest in an entire genre:
Habitat looks like a ton of fun. It's a space simulation where you try and build a new home for humanity out of space debris. I have one question though: How did the statue of Liberty's head get into space!?
Knight Squad describes itself as a cross between Bomberman and Gauntlet, for up to 8 players:
Spectra looks a little bit like a low-res F-Zero, except it's set to the sounds of Chipzel, who created the music for Super Hexagon.
With Sony's big indie push last year, it's good to see that Microsoft has some great-looking indie games in the works along with their AAA titles.