Lisa The Painful RPG takes place in a world where there are no women. Only men. Given the extreme subject matter its creator, Austin Jorgensen, could have gone the "funny" route or the "bleak as hell" route. He's gone the latter.
Described as a "game about survival, sacrifice, and perverts", it's set in a world where the disappearance of women has, as you'd expect, brought out the worst in the men. There are a lot of beards, and a lot of blood.
In order to add to the gravity of it all, Jorgensen wants there to be really heavy decisions available for the player to make, like "Giving up your limbs in exchange for the lives of your party members". Cheery.
Another neat feature is that he's making sure every single character in the game, including every NPC, is a unique entity, not simply a reskinned template or cut-n-paste job.
Due on PC, the game's currently up on Kickstarter. Feel free to back it if you enjoyed Y: The Last Man or like awesome t-shirt rewards.