If you understand this reference, you should probably play LEGO Marvel’s Avengers. I’m currently battling the urge to collect all the bits while playing through the game for review, but in terms of pure Marvel cinematic universe fan service it’s a magical place.
Commander Shepard and Agent Coulson had a crossover. But, it's not the good kind. See, some concept drawing for BioWare's popular sci-fi video game saga apparently got swiped in a recent episode of the Marvel Entertainment television series. And some eagle-eyed Mass Effect fans spotted it.