The percentage of the gaming population who plays "Southpaw" style is unknown. But what was uncovered quickly, was that Xbox 360 title Ghost Recon Advanced Warfighter didn't have a "Southpaw" control scheme. TeamXbox links to an official response on the UbiSoft boards and it is promising. Here's the good word: "Southpaw will not be available at ship. We have the message, the appropriate people have been notified." Good news for an Xbox Live update down the road, it would seem.

Official Response on GRAW's Lack of Southpaw Options [TeamXbox]
Southpaw - Official Response [UbiSoft]

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