Well, Destiny, that didn't take long. Speaking with Destructoid, Bungie's co-founder Jason Jones says something that anyone reading this with mouse in hand at keyboard at front might find a little... weird.
We did a bunch of ambitious things on Halo deliberately to reach out to people. We limited players to two weapons, we gave them recharging health, we automatically saved and restored the game—almost heretical things to first-person shooters at the time. We made the game run without a mouse and keyboard. And now nobody plays shooters the way they used to play them before Halo 'cause nobody wants to.
Interviews are funny things. You could argue that the "nobody plays shooters the way they used to play them" bit applies to the design changes made, and he just threw the mouse & keyboard comment in there at an inopportune time. Let's hope that's the case.
You may have noticed already that the game, the studio's first effort since leaving the Halo franchise behind, has been announced for consoles and not the PC.
Bungie says 'nobody plays shooters the way they used to' [Destructoid]
UPDATE - I originally wrote this post having read a little too much into Jones' statement, particularly the "mouse & keyboard" stuff. It's since been edited.