Combine a difficult surgery simulator with a virtual reality headset and a fancy control system and you get...the physical effects of being super drunk, sans the bravado (and the hangover).
Yes, this is nothing more than Surgery Simulator 2013 paired with the Oculus Rift virtual reality headset and Razer Hydra motion-control system. Three things that have nothing to do with drinking. Until you see this guy trying to move his hands, and realise it's giving him the sensation of them being his hands.
Surgeon Simulator with the Rift and Hydra [rigaudio]