Good news: Dragon Age: Inquisition is pretty great. Less-good news: Being a story-heavy role-playing game, it relies heavily on a familiarity with the Dragon Age series' dense lore. Newcomers might be a bit lost at times.
I get the sense that a lot of people who missed the first two games are going to give this one a shot. As well they should! Skipping right to Inquisition is definitely doable, but in order to have the best time, you'll probably want to brush up on your lore up front. And that's what I'm here for.