That kind of weighty aspiration is exactly what Unwritten: That Which Happened is aiming for. The in-development PC game being made by Roxlou Games' Joe Houston, who worked most recently on Dishonored. The Kickstarter page describes it as a roguelike RPG hybrid where decisions and death are permanent and lasting. And players will be able to make their own quests for each other to play.
Unwritten looks like it could address a lot of the issues people say they have with narrative delivery in games, where choices made in a campaign don't seem to matter and the stakes feel too small. If you like the ideas floating around in the pitch video, head over to the project page to learn more.