I've played a lot of Far Cry 3. A looooot. And so I'm always looking for ways to freshen up the game for another go-round. I got about halfway through on a second playthrough, but it still didn't seem quite different enough for me.
Fortunately, PC modders have wasted no time coming up with clever ways to shake things up. I've been watching the recently-launched Far Cry Nexus with bated breath, waiting for the first major overhaul to launch, so that I might try it out.