While Kinect developers struggle to wrangle a decent non-dancing game experience out of Microsoft's peripheral, indie PC studio Indomitus Games are working on a PC game where you need a microphone. Because your voice will be the only way you can get stuff done.
In Verbis Virtus is an upcoming fantasy title where you play as some kind of magician, and to cast the spells required to overcome puzzles you need to actually say the words.
Which might get tiring depending on the variety of spells, but I'm going to remain optimistic, because the trailer above looks pretty good!
If you want to try it out now, there's a demo available on Indomitus' site.