Gameplay as cinema? Sure, it can work, especially when it's as entertaining as Run, a short clip put together by YouTube user JackFrags.
While captured in-game, this isn't raw, live gameplay footage. Those aren't competitive opponents he's up against (in case you couldn't tell by the Stormtrooper-like accuracy and reflexes on display.
Everyone you see is just an "actor", playing their part in this piece of first-person entertainment. Think of it as a day in Rambo's life and you're set.