Towards the end of inFamous, Cole MacGrath is given a vision of The Beast, an all-powerful world destroyer that only he has the power to stop. At the beginning of Infamous 2, he fails.
Infamous lovingly sets Cole up for a fall in Infamous 2. As the game begins The Beast arrives in Empire City, and our hero finds himself powerless to stop it. Instead he flees south to New Marais to rest, recoup, and build up the kind of power necessary to save the planet from total destruction.
The stage is set. Now all we have to do is wait until Infamous 2 hits the PlayStation 3 on June 7.
inFAMOUS 2: The Beast is Coming [PlayStation Blog]