The next Pokemon series, Pokemon: Black & White, is all new Pocket Monsters right up until the end. As previously posted, the anime has two old friends.
But the anime Ash (who is called "Satoshi" in Japan) looks slightly different. Commenters have pointed out that Ash's eyes look different from the way they have looked in previous anime.
Ash isn't the only one that is getting a slight make-over. Nurse Joy and Officer Jenny look different, too.
Maybe, though, this isn't Ash! Doubt it because that would be confusing for little kids, but maybe. Maybe it's his twin. He's twin with big brown eyes. Or his evil twin? Not likely.