In normal Spider-Man continuity, a burglar Peter Parker lets escape kills his Uncle Ben. In Spider-Man Noir continuity, former circus freak Adrian Toomes, a.k.a. the Vulture, eats Uncle Ben. You can avenge the Vulture's dinner in Spider-Man: Shattered Dimensions.
Technically Spider-Man Noir already took care of vengeance, killing the Vulture in issue four after the villain kidnaps Aunt May and tries to kill her. The Noir version of the Vulture is not a nice guy. I shall enjoy giving him the first-person smack down once Spider-Man: Shattered Dimensions hits stores next month.