I think it means the sequel to Infamous is gonna be called Infamous 2: The Game Dot Com!
Look, we already knew that the PS3 exclusive had started casting voice acting for a sequel. And while it was a new title, unless the thing completely sucks a heavily hyped new IP is more likely to get a sequel than not.
The site was registered by Sony Computer Entertainment America on Tuesday. Discovered, of course, by the registry sleuth Superannuation. That reminds me, I'm gonna go register www.superannuationtheblogthegame.com