The game will let players import and customize their avatars. Players will be able to choose the instrument each avatar plays, as well as choosing their band mates. The game will still have in-game characters including Guitar Hero classics like Judy Nails, Axel Steel and Lars Umlaut.
Guitar Hero 5 will also include a Create-A-Rocker mode with Guitar Hero clothing and accessories for the avatars.
Activision told Kotaku that while the game will not support Home avatars on the PS3 version of Guitar Hero 5, it will let Wii gamers use their Miis in the Mii Freestyle Mode.
The game, which features 85 tracks, is due out on Sept. 1