Atari's Ghostbusters: The Video Game is coming to every platform it possibly can. Obviously those various ports are going to be very different. The Nintendo DS experience isn't going to match the PlayStation 3 experience.
Atari's being very clear about this with the game's box art. The Wii, PlayStation 2 and Nintendo DS versions get the caricature version seen on the left, while the PlayStation 3, Xbox 360 and PC versions get the more photo realistic version on the right. The aesthetic even applies to the game's cover specters, with slightly less menacing ghosts featured on the lower-definition, E-10+ rated version.
Not totally unexpected, but a rare instance of a publisher being so forthcoming about the platform differences on the box art.