A "source" speaking with Joystiq seems to think so. According to this source - who is "close to the deal" - developers Naughty Dog have already agreed to option the rights to a movie based on their 2007 hit (and our 2007 NQGOTY), with Atlas Entertainment reported to be behind the project. Who are Atlas? They're a production company who helped put Twelve Monkeys and Three Kings together, so relax, will you?
Source: Uncharted optioned for movie adaptation [Joystiq]